BOVINE COLOSTRUM: STUDIED, SAFE, NATURAL

What is Colostrum?


Colostrum is the pre-milk substance produced by female mammals following the birth of the newborn. Colostrum supplies immune and growth factors and a perfect combination of vitamins and minerals to activate the immune system and ensuring health, vitality and growth of the newborn.

Over 2,000 research papers strongly support both colostrum and its numerous components for Immune Health, Gut Health, Sports Performance and Recovery. Numerous studies show that colostrum and its components continue to provide important benefits when given to adults with no reports of allergic or anaphylactic reactions.

All ImuniPro Colostrum products are antibiotic, rBST free and tested from collection at the dairies to the finished product. Through over 300 Standard Operation Prodecures that control all aspects of the production process and adherence to Good Manufacturing Practices (GMPs), our products are continually checked for potency and safety.

The immunoglobulin type G (IgG) content of colostrum is the traditional measure of its quality and effectiveness. IgG are tested and quantified in each batch of colostrum powders to ensure quality for maximum effectiveness.

Download the monograph of Colostrum bovine by clicking on the PDF icon above

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Typical composition of Skim Colostrum Powder

The most important components of colostrum can be broken down into three major categories: Immune System Factors, Growth Factors and Nutritional Components.

Immune System Factors

The most abundant immune factors found in colostrum are:

Immunoglobulins (A, D, E, G and M) are the most abundant of the immune factors found in colostrum. Immunoglobulins G (IgG) neutralize toxins and microbes in the lymph and circulatory system. Immunoglobulins have been documented to provide a superior defence in both treatment and prevention of viral infections, bacteria and yeast.1, 2, 3 Local protection in the form of bovine colostrum antibodies has been shown to provide local protection to the gastrointestinal tract.4
PRPs regulate the thymus gland, stimulating an under active immune system or down-regulating an overactive immune system.5 PRPs function to modulate the immune system, promote T-lymphocyte function and can stimulate the lymphocytes to become either helper T-cells or suppressor T-cells.5 PRPs stimulate the activity of NK cells up to 10 times, far greater than any other known substance. NK cells are the cells that attack and kill pathogens and cancerous cells. 6 PRPs have been experimentally shown to provide immunity to several viruses, including herpes viruses,7, 8, 9 HIV,10 and measles.11
Lactoferrin is another key component of colostrum. It is secreted in milk, tears, mucus, and saliva, particularly in response to a pathogen attack. Its biological activities include anti-inflammatory, anti-cancer, antibacterial, antiviral, and anti-fungal functions.12 Its anti-pathogenic activities relate primarily to its ability to bind iron and thus starve pathogens, which require iron as a nutrient.12

Growth Factors

Growth factors are proteins or polypeptides that bind to receptors on the cell surface, with the primary result of activating cellular proliferation and/or differentiation.13
The most abundant of the growth factors found in colostrum are:13

  • Epithelial growth factor (EgF).
  • Insulin-like growth factor I and II (IGF-I and IGF-II).
  • Fibroblast growth factor (FgF).
  • Platelet-derived growth factor (PDGF).
  • Transforming growth factors (TGF).
  • Growth hormone (GH).

IGF-I, TGF and EGF growth factors are of specific interest in regard to athletic performance and the anti-aging process.14, 15

  • Stimulate muscle and bone cell proliferation and development.
  • Stimulate tissue repair and wound healing.

Nutritional Components

Colostrum is a combination of vitamins (A, B1, B2, B6, B12, E), minerals (Calcium, Sodium, Magnesium, Zinc) and amino acids (essential and non-essential) that are naturally occurring in a perfect combination.

Colostrum is a source of essential fats, including phospholipids which have beneficial health effects:16

  • Regulation of inflammatory reactions.
  • Inhibition of the cholesterol absorption.
  • Improvement of brain functions.
  • Improvement of hyperactivity disorder.
  • Improvement of endurance athletes.

The Benefits of ImuniPro Colostrum Powders

ImuniPro Colostrum products provide high levels of IgG and are a natural source of Immune System Factors, Growth factors, Nutritional Components and Essential fats, including Phospholipids.

Certified Quality Assurance & Safety


ImuniPro Colostrum is monitored and traced from collection at the dairies to the finished product. With world-class quality assurance, 42 separate tests are conducted on raw colostrum and over 50 tests are conducted on the finished colostrum prior to shipment.

Protein, fat, lactose, ash, and moisture are recorded. Aerobic Plate Count (APC or SPC), Coliform bacteria, E. coli, Salmonella spp., Listeria spp., Staphylococcus aureus, Shigella spp., Bacillus cereus, Enterobacteriaceae spp. and Yeast and Mould testing is performed along with other microbiological tests as required.

The immunoglobulin type G (IgG) content of colostrum is the traditional measure of its quality and effectiveness. IgG is tested and quantified using High Performance Liquid Chromatography (HPLC) in each batch of colostrum powders.

There are over 300 Standard Operating Procedures that control all aspects of the production process. Every step of manufacturing, material handling, finished goods release, line clearance, employee training and certified Good Manufacturing Practices (cGMPs) are documented. Thirty-two cameras show every movement in the factory. Remote access allows us consistently follow all manufacturing process variables.

REFERENCES

1. Bishop GA, Haxhinasto SA, Stunz LL, Hostager BS. Antigen-specific B-lymphocyte activation. Crit Rev Immunol, 2003;23(3):149-97.
2. Ferrer-Argote VE, Romero-Cabello R, Hernandez-Mendoza L, et al. Successful treatment of severe complicated measles with non specific transfer factor. In Vivo, 1994;8(4):555-7.
3. Van Hooijdonk AC, Kussendrager KD, Steijns JM. In vivo antimicrobial and antiviral activity of components in bovine milk and colostrum involved in non-specific defence. Br J Nutr, 2000;84
4. Thapa BR. Therapeutic potentials of bovine colostrums. Indian J Pediatr. 2005 Oct;72(10):849-52. Review.
5. Zimecki M, Artym J. Therapeutic properties of proteins and peptides from colostrum and milk. Postepy Hig Med Dow (Online), 2005;59:309-23.
6. See, DM, Khemka, P, Sahl, L, Bui, T, Tilles, JG. The role of natural killer cells in viral infections. Scandinavian Journal of Immunology, 1997; 46(3):217-224.
7. Pizza G, Meduri R, De Vinci C, et al. Transfer factor prevents relapses in herpes keratitis patients: a pilot study. Biotherapy, 1994;8(1):63-8.
8. Pizza G, Viza D, De Vinci C, et al. Orally administered HSV-specific transfer factor (TF) prevents genital or labial herpes relapses Biotherapy, 1996;9(1-3):67-72.
9. Meduri R, Campos E, Scorolli L, et al. Efficacy of transfer factor in treating patients with recurrent ocular herpes infections. Biotherapy, 1996;9(1-3):61-6.
10. Raise E, Guerra L, Viza D, et al. Preliminary results in HIV-1-infected patients treated with transfer factor (TF) and zidovudine (ZDV). Biotherapy, 1996;9(1-3):49-54.
11. Ferrer-Argote VE, Romero-Cabello R, Hernandez-Mendoza L, et al. Successful treatment of severe complicated measles with non-specific transfer factor. In Vivo, 1994;8(4):555-7.
12. Giansanti F, Panella G, Leboffe L, Antonini G. Lactoferrin from Milk: Nutraceutical and Pharmacological Properties. Pharmaceuticals, 2016; 9(4):61. Review.
13. Gauthier S, Pouliot Y, Maubois JL. Growth factors from bovine milk and colostrum: composition, extraction and biological activities. Le Lait, INRA Editions, 2006; 86(2):99-125
14. Ahmadi-Vincu M, et al. Colostrum as nutritional supplement in sport. Scientifical Researches. Agroalimentary Processes and Technologies, 2005; XI (1):33-40
15. Rudman D, et al. Effects of Human Growth Hormone in Men over 60 Years Old. N. Eng. J. Med, 1990; 323:1-6.
16. Kϋllenberg D, Taylor LA, Schneider M, Massing U. Health effects of dietary phospholipids. Lipids Health Dis, 2012 Jan 5;11:3.